Epi-inositol is ineffective in Porsolt Forced Swim Test model of depression
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چکیده
منابع مشابه
Epi-inositol is ineffective in Porsolt Forced Swim Test model of depression
The six-carbon polyol inositol is a uniquely versatile compound in biology. Myo-inositol is the major naturally occurring isomer of nine possible inositol isomers and is critical for the phosphoinositide (PI) cycle as a substrate for PI synthase (Berridge and Irvine 1989). Benjamins and Agranoff (1969) reported that epi-inositol is not a substrate for PI synthase, but a number of experiments su...
متن کاملThe mouse forced swim test.
The forced swim test is a rodent behavioral test used for evaluation of antidepressant drugs, antidepressant efficacy of new compounds, and experimental manipulations that are aimed at rendering or preventing depressive-like states. Mice are placed in an inescapable transparent tank that is filled with water and their escape related mobility behavior is measured. The forced swim test is straigh...
متن کاملThe antidepressant activity of inositol in the forced swim test involves 5-HT(2) receptors.
The effect of inositol as an antidepressant was previously demonstrated in both animal models of depression-like behavior and in clinical trials. Unlike most antidepressant drugs, inositol does not have a clear target in the synapse and was not demonstrated to alter monoamine levels in the brain. The present study attempted to draw a psychopharmacological profile of inositol's behavioral effect...
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Lithium inhibits IMPase (inositol monophosphatase) activity, as well as inositol transporter function. To determine whether one or more of these mechanisms might underlie lithium's behavioural effects, we studied Impa1 (encoding IMPase) and Smit1 (sodium-myo-inositol transporter 1)-knockout mice. In brains of adult homozygous Impa1-knockout mice, IMPase activity was found to be decreased; howev...
متن کاملEvaluation of antidepressant activities of rose oil and geranium oil in the forced swim test in mouse
Depression is one of the most common psychiatric disorders that may result in significant consequences in active population of the society. In traditional manuscripts there are many indications about the antidepressant effects of rose oil, but so far no scientific research has been done about this subject. The purpose of present study was to determine the antidepressant effects of rose oil and ...
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ژورنال
عنوان ژورنال: Neuropsychiatric Disease and Treatment
سال: 2005
ISSN: 1176-6328
DOI: 10.2147/nedt.1.2.189.61052